| Healthcare SC | Jenkinsville | 254 | | Closure |
| PepsiCo Beverages Sales | Columbia | 105 | | Layoff |
| Electrolux Consumer Products | Anderson | 10 | | Layoff |
| 80 Acres Urban Agriculture, Inc. (80 Acres Farms) | Anderson | 73 | | Layoff |
| Pactiv | Aiken | 133 | | Closure |
| ILPEA Industries | Anderson | 14 | | Closure |
| Kpr US | Lugoff | 3 | | Closure |
| Kpr US | Lugoff | 13 | | Closure |
| Kpr US | Lugoff | 16 | | Temporary Closure |
| Electrolux Consumer Products | Anderson | 1,245 | | Layoff |
| Electrolux Consumer Products | Anderson | 1,255 | | Layoff |
| Electrolux Consumer Products | Anderson | 1,139 | | Layoff |
| Swiss Krono | Barnwell | 99 | | Layoff |
| Swiss Krono | Barnwell | 130 | | Layoff |
| ILPEA Industries | Anderson | 43 | | Closure |
| Hengst Filtration | Lugoff | 77 | | Layoff |
| thyssenkrupp Supply Chain Services | Spartanburg | 110 | | Layoff |
| Univar Solutions USA | Spartanburg | 99 | | Layoff |
| Industrial Plastics Group | Easley | 74 | | Layoff |
| ABM Industry Groups | Charleston | 122 | | Layoff |
| Kpr US | Lugoff | 23 | | Closure |
| Textron Systems | Goose Creek | 58 | | Layoff |
| Kpr US | Lugoff | 19 | | Closure |
| SMBC MANUBANK (JeniusBank) | Charleston | 1 | | Layoff |
| Charter Communications | Greenville | 62 | | Closure |
| C2 Technologies | Columbia | 1 | | Layoff |
| Railcrew Xpress | Charleston | 12 | | Closure |
| Railcrew Xpress | Charleston | 1 | | Closure |
| Railcrew Xpress | Charleston | 58 | | |
| Parsec | Charleston | 39 | | Closure |
| First Brands Group, LLC (AVM) | Mullins | 64 | | Closure |
| Koppers | Florence | 66 | | Layoff |
| SMBC MANUBANK (JeniusBank) | Charleston | 3 | | |
| Milliken (Cedar Hill Plant) | Union | 126 | | Closure |
| Milliken (Cedar Hill Plant) | Jonesville | 126 | | |
| James Hardie Building Products | Summerville | 78 | | Closure |
| DLH Solutions | Charleston | 194 | | Layoff |
| eREV Supply Chain | Charleston | 133 | | Layoff |
| Saddle Creek Logistics Services | Spartanburg | 130 | | Layoff |
| WeDriveU | Charleston | 194 | | Closure |
| SC Industrial Holdings | Greenville | 78 | | Temporary Closure |
| Best Dressed Chicken | Saluda | 4 | | Layoff |
| House of Raeford | Hemingway | 216 | | Temporary Layoff |
| Sodexo (HCA Grand Strand Medical) | Myrtle Beach | 85 | | Layoff |
| Atkore Plastics Southeast | York | 42 | | Layoff |
| Atkore Plastics Southeast | Fort Mill | 1 | | |
| East Coast Migrant Head Start Project | Raleigh | 10 | | Temporary Layoff |
| East Coast Migrant Head Start Project | Raleigh | 1 | | Temporary Layoff |
| East Coast Migrant Head Start Project | Raleigh | 9 | | |
| PL Developments | Greenville | 8 | | Layoff |
| Santee Print Works | Sumter | 140 | | Closure |
| PL Developments | Piedmont | 114 | | Layoff |
| IG Design Group Americas | Batesburg-Leesville | 1 | | Closure |
| IG Design Group Americas | Batesburg-Leesville | 10 | | |
| Anchor Bar of Myrtle Beach | Myrtle Beach | 29 | | Closure |
| WeDriveU | Charleston | 215 | | Closure |
| KIRA Services | Beaufort | 11 | | Layoff |
| Cooperative Health | Columbia | 80 | | Layoff |
| Sodexo, Inc. and Affiliates | York | 177 | | Layoff |
| Quality Built | Charleston | 7 | | Closure |
| Quality Built | Charleston | 3 | | Closure |
| IG Design Group Americas | Batesburg-Leesville | 112 | | Closure |
| Elliott Sawmilling Co., LLC (dba Canfor Southern Pine) | Hampton | 170 | | Closure |
| NSLC Darlington, Inc. (dba Canfor Southern Pine) | Darlington | 120 | | Closure |
| CEF Solutions | Greenville | 108 | | Layoff |
| CACI | Sumter | 109 | | Layoff |
| Sodexo | Newberry | 210 | | Layoff |
| DAV-Force | Goose Creek | 76 | | Layoff |
| Sodexo | Newberry | 6 | | |
| DAV-Force | Goose Creek | 8 | | |
| Compass Group USA, Inc. DBA Chartwells | Spartanburg | 350 | | Layoff |
| Bicycle Corporation of America (Kent) | Manning | 64 | | Closure |
| Ron Group, LLC (dba Blue Sky Specialty Pharmacy) | Charleston | 125 | | Layoff |
| Ron Group, LLC DBA Blue Sky Specialty Pharmacy | Mount Pleasant | 125 | | Layoff |
| Ron Group, LLC (dba Blue Sky Specialty Pharmacy) | Mount Pleasant | 6 | | |
| Limestone University | Gaffney | 478 | | Closure |
| Hood Container | Greenville | 60 | | Closure |
| MetoKote | Greenville | 113 | | Closure |
| Proterra Powered | Greenville | 7 | | Layoff |
| Proterra Powered | Greenville | 85 | | Layoff |
| Tupperware | Hemingway | 102 | | Closure |
| Tupperware | Hemingway | 4 | | |
| ASRC Federal | Charleston | 292 | | Layoff |
| ASRC Federal | North Charleston | 319 | | Layoff |
| Yokohama TWS North America | Spartanburg | 90 | | Closure |
| Boeing | North Charleston | 8 | | Layoff |
| SC Industrial Holdings (dba Palmetto State Armory) | Greenville | 78 | | Temporary Closure |
| D&A Consulting | | 13 | | Layoff |
| Vimo | | 9 | | Layoff |
| Atrium Hospitality | Columbia | 120 | | Closure |
| McKesson Medical-Surgical | York | 179 | | Layoff |
| Natural Fiber Welding | Greenville | 1 | | Layoff |
| Boeing | North Charleston | 67 | | Layoff |
| Denkai America | Lugoff | 60 | | Closure |
| PL Developments | Laurens | 113 | | Closure |
| Boeing | North Charleston | 220 | | Layoff |
| Rich Products Corporation (Rich's) | Laurens | 25 | | Closure |
| Rich Products Corporation (Rich's) | Fountain Inn | 184 | | Closure |
| Rich Products Corporation (Rich's) | Fountain Inn | 1 | | |
| International Paper | Georgetown | 675 | | Closure |