| Cornerstone Building Brands | Kearney | 61 | | Layoff |
| FedEx | Earth City | 75 | | Closure |
| FedEx | St. Louis | 68 | | Closure |
| Compass Group USA, Inc. d/b/a Chartwells | Chesterfield | 93 | | |
| Schnuck Markets | Bridgeton | 64 | | Closure |
| Charter Communications | Town & Country | 107 | | Closure |
| Great Southern Bank | | 45 | | Closure |
| Nature’s Bakery | Hazelwood | 345 | | Closure |
| Conduent Commercial Solutions | | 8 | | Layoff |
| St. Louis Post-Dispatch | Maryland Heights | 3 | | Closure |
| Bausch & Lomb | | 119 | | Layoff |
| SMBC Manubank | | 1 | | Layoff |
| General Mills | St. Charles | 6 | | Closure |
| Timken Belts | Springfield | 283 | | Closure |
| Nike IHM, Inc (dba AirMI) | St. Charles | 172 | | Layoff |
| Trilogy Warehouse Partners | St. Louis | 67 | | Layoff |
| Durham School Services | House Springs | 107 | | |
| General Mills Operations | St. Charles | 163 | | Closure |
| Oracle | Kansas City | 539 | | Layoff |
| Saks & | St. Louis | 65 | | Closure |
| Main Street Sports Group | St. Louis | 25 | | Closure |
| Community Wholesale Tire Dis | Hazelwood | 143 | | Closure |
| St. Louis Post-Dispatch | Maryland Heights | 3 | | Closure |
| National Aviation Services (NAS) | St. Louis | 48 | | |
| Greenbrier Manufacturing | Kennett | 94 | | |
| TelaForce | Kansas City | 104 | | |
| TelaForce | Kansas City | 106 | | |
| Saint Francis Healthcare | Poplar Bluff | 213 | | Layoff |
| Simmons Animal Nutrition | Milan | 151 | | Closure |
| Nordstrom Credit Operations/Nordstrom Credit Bank | St. Louis | 1 | | Layoff |
| Hollister | Kirksville | 7 | | Closure |
| Home Care Delivered | St. Louis | 1 | | Layoff |
| St. Louis Dispatch | Maryland Heights | 3 | | Closure |
| Lawn and Garden | Excelsior Springs | 93 | | Layoff |
| Hollister | Kirksville | 5 | | Closure |
| United BioSource | Kansas City | 123 | | Closure |
| Chase Smiles Logistics | Hazelwood | 77 | | |
| Larken Logistics | Fenton | 118 | | Closure |
| Block | St. Louis | 23 | | Layoff |
| Hollister | Kirksville | 11 | | Closure |
| St. Louis Dispatch | Maryland Heights | 4 | | Closure |
| Hollister | Kirksville | 3 | | Closure |
| Home Depot | Mexico | 61 | | Closure |
| Panera | St. Louis | 72 | | Closure |
| ImageFIRST Healthcare Laundry Specialists | St. Louis | 92 | | |
| Hollister | Kirksville | 7 | | Closure |
| Priority Yard & Train | Kansas City | 75 | | Layoff |
| St. Luke’s Episcopal - Presbyterian Hospital | St. Louis | 336 | | Closure |
| Nordstrom | St. Louis | 135 | | Closure |
| Cenlar | O'Fallon | 93 | | Closure |
| Pharma Tech Industries | Union | 84 | | Closure |
| First Student | Holden | 257 | | Layoff |
| Briggs & Stratton - Billy Goat Facilities | Lee's Summit | 90 | | Closure |
| Penske Logistics | Kinloch | 337 | | |
| SP Plus, LLA, A Metropolis | St. Louis | 130 | | |
| Accelerate 360 Distribution | Earth City | 22 | | Layoff |
| Broadridge Financial Services | Kansas City | 72 | | Closure |
| Spectrum Healthcare Resources | St. Louis | 280 | | |
| Block | St. Louis | 67 | | Layoff |
| Hogan Services | St. Louis | 53 | | Layoff |
| Sodexo | Jefferson City | 63 | | |
| Student Transportation of America | Columbia | 212 | | |
| Legacy Pharmaceuticals Solutions | Earth City | 77 | | Closure |
| International Paper | St. Louis | 72 | | Closure |
| True Value | Kansas City | 50 | | Closure |
| Fontbonne University | St. Louis | 80 | | Closure |
| Jack Cooper | Wentzville | 239 | | Closure |
| Royal Canin North America | Rolla | 105 | | Closure |
| International Institute St. Louis | St. Louis | 91 | | Layoff |
| Hollister | Kirksville | 1 | | Closure |
| Eaton Bussman | Ellisville | 57 | | Layoff |
| Roi CPS | Republic | 109 | | Closure |
| Jack Cooper | Liberty | 406 | | Closure |
| The TimKen | Springfield | 97 | | Closure |
| Vimo, Inc. DBA GetInsured | Jackson | 4 | | Layoff |
| Silgan Plastics | Hazelwood | 33 | | Closure |
| Hollister | Kirksville | 3 | | Layoff |
| Gate Gourmet | Berkeley | 102 | | Layoff |
| Boeing | Berkeley | 692 | | Layoff |
| Martinrea | Riverside | 144 | | Layoff |
| Sodecia Automotive Kansas City | Kansas City | 111 | | Layoff |
| St. Louis Post Dispatch | Maryland Heights | 73 | | Closure |
| International Paper | Kansas City | 132 | | Closure |
| Geha | Lee's Summit | 453 | | Layoff |
| True Value, Kansas City | Kansas City | 69 | | Closure |
| Output Services Group | Earth City | 79 | | Closure |
| Owens & Minor | Kansas City | 67 | | Closure |
| Kaleo | St. Louis | 2 | | Layoff |
| Cygnus Home Service, LLC DBA Yelloh | Fenton | 32 | | Layoff |
| Yanfeng | Riverside | 444 | | Layoff |
| Adient | Riverside | 172 | | Layoff |
| Signature Psychiatric Hospital | North Kansas City | 154 | | Closure |
| Southern Glazers | St. Charles | 94 | | Layoff |
| Omega Healthcare | Oak Grove | 2 | | Layoff |
| Otscon | Columbia | 160 | | Closure |
| The Cheesecake Factory | Chesterfield | 101 | | Closure |
| Cherokee Nation Federal Consulting | Kansas City | 187 | | Layoff |
| Oregon Tool | Kansas City | 80 | | Layoff |
| Cygnus Home Service, LLC DBA Yelloh | Carthage | 44 | | Layoff |
| Regency Enterprises Services | St. Louis | 183 | | Layoff |