| Spirit & Sanzone Distributors Co., Inc | East Syracuse | 64 | 2020-04-27 | Closure |
| Comfort Systems USA, Inc. (Syracuse) | East Syracuse | 119 | 2020-04-03 | Layoff |
| Sports Physical Therapy of New York, PC | East Syracuse | 59 | 2020-03-24 | Layoff |
| Chesapeake Hospitality (Doubletree by Hilton Downtown Syracuse) | East Syracuse | 0 | 2020-03-20 | Layoff |
| New York Express and Logistics, LLC (East Syracuse) | East Syracuse | 15 | 2019-12-30 | |
| New York Express and Logistics, LLC (East Syracuse) | East Syracuse | 15 | 2019-12-30 | Closure |
| Empire Vision Center, Inc. (Visionworks - Central Lab) | East Syracuse | 73 | 2019-02-28 | Closure |
| New England Motor Freight (NEMF) East Syracuse Terminal | East Syracuse | 63 | 2019-02-14 | Closure |
| Advanced Motors and Drives (Nidec Kinetek Company) | East Syracuse | 51 | 2018-07-17 | Layoff |
| Osmose Utilities Services, Inc | East Syracuse | 101 | 2018-01-12 | Closure |
| Auburn Armature, Inc.(East Syracuse) | East Syracuse | 9 | 2017-04-21 | Closure |
| Johnson Controls, Inc. @ Bristol Myers Squibb | East Syracuse | 39 | 2015-05-01 | Closure |
| UNY, LLC a/k/a General Super Plating | East Syracuse | 95 | 2015-04-20 | Closure |
| Reit Management & Research LLC | East Syracuse | 2 | 2014-06-30 | Closure |
| Advanced Motors and Drives | East Syracuse | 34 | 2014-03-06 | Layoff |
| New Process Gear, Inc. (Division of Magna Powertrain) | East Syracuse | 1 | 2012-09-12 | Closure |
| New Process Gear, Inc. (Division of Magna Powertrain) | East Syracuse | 406 | 2012-05-23 | Closure |
| New Process Gear, Inc. (Division of Magna Powertrain) | East Syracuse | 139 | 2011-10-05 | Closure |
| New Process Gear, Inc. (Division of Magna Powertrain) | East Syracuse | 1 | 2011-09-30 | Closure |
| New Process Gear, Inc. (Division of Magna Powertrain) | East Syracuse | 498 | 2011-09-09 | Closure |
