| CTG, Inc. (at IBM-Anthem site) | Buffalo | 84 | 2021-06-22 | Closure |
| Sonwil Distribution Center, Inc | Buffalo, Depew, Orchard Park | 237 | 2021-06-03 | Layoff |
| Allied Universal | Buffalo | 28 | 2020-12-08 | |
| Universal Protection Services, LLC d/b/a Allied Universal Security Services (at GM - Tonawanda) | Buffalo | 28 | 2020-12-08 | Layoff |
| Southwest Airlines Co. (Buffalo Niagara Int'l Airport) | Buffalo | 0 | 2020-12-03 | Temporary Layoff |
| CGI Federal Inc. (at the New Passport office, Buffalo) | Buffalo | 4 | 2020-10-01 | Layoff |
| Le Tote, Inc. (Buffalo) | Buffalo | 39 | 2020-10-01 | Closure |
| SP+ (at Buffalo Niagara International Airport) | Buffalo | 90 | 2020-09-24 | Layoff |
| Dave & Busters (Buffalo) | Buffalo | 85 | 2020-09-08 | Layoff |
| P.F. Chang's China Bistro (Buffalo) | Buffalo | 64 | 2020-09-04 | Temporary Closure |
| Avis Budget Car Rental, LLC (Buffalo) | Buffalo | 0 | 2020-08-28 | Temporary Layoff |
| Faculty Student Association of State University of New York at Buffalo, Inc., dba Campus Dining and Shops, and UBFSA Services LLC dba Three Pillars Catering | Buffalo | 1,401 | 2020-07-22 | Closure |
| New Era Cap Company, Inc | Buffalo | 117 | 2020-07-07 | Layoff |
| Delaware North Companies, Inc. (Several Western Region sites) | Buffalo | 1,383 | 2020-06-30 | Layoff |
| Allpro Parking, LLC (31 Erie County sites) | Buffalo | 92 | 2020-06-24 | Layoff |
| YMCA Buffalo Niagara (9 sites) | Buffalo/Amher st/Kenmore/L ancaster/Lockport/Niagara | 909 | 2020-06-17 | Closure |
| Bands Visit National Tour LLC (Western) | Buffalo | 0 | 2020-06-16 | Closure |
| Hyatt Regency Buffalo Hotel (Fountain Plaza- Buffalo) | Buffalo | 207 | 2020-05-26 | Closure |
| Hyatt Regency Buffalo Hotel (Fountain Plaza-Buffalo) | Buffalo | 207 | 2020-05-26 | Closure |
| Buffalo Niagara Convention Center Management Corporation | Buffalo | 35 | 2020-04-29 | Layoff |
