| HMS Host Family Restaurants, Inc. (Syracuse Regional Office) | Syracuse | 7 | 2021-04-27 | Closure |
| Durham School Services, L.P | Syracuse | 67 | 2021-03-31 | Closure |
| Best Buy (Store #538) | Syracuse | 70 | 2021-01-17 | Closure |
| National Express Group, PLC | Syracuse | 87 | 2020-11-23 | |
| National Express (Syracuse) | Syracuse | 87 | 2020-11-23 | Temporary Layoff |
| Aramark Campus, LLC (Lakeview Amphitheater) | Syracuse | 110 | 2020-10-16 | Temporary Layoff |
| Le Tote, Inc. (Syracuse) | Syracuse | 45 | 2020-10-01 | Closure |
| Dave & Busters (Syracuse) | Syracuse | 77 | 2020-09-08 | Layoff |
| P.F. Chang's China Bistro (Syracuse) | Syracuse | 68 | 2020-09-04 | Temporary Closure |
| Avis Budget Car Rental, LLC (2 Central sites) | North Syracuse | 0 | 2020-08-28 | Temporary Layoff |
| Delaware North Companies, Inc. (DN Syr LLC) (Syracuse) | Syracuse | 54 | 2020-06-30 | Layoff |
| Allpro Parking, LLC (Syracuse) | Syracuse | 2 | 2020-06-24 | Layoff |
| J.C. Penney (Destiny USA Shopping Center, Syracuse) | Syracuse | 91 | 2020-06-22 | Closure |
| Spirit & Sanzone Distributors Co., Inc | East Syracuse | 64 | 2020-04-27 | Closure |
| Crescent Hotels & Resorts LLC, dba Marriott Syracuse Downtown | Syracuse | 142 | 2020-04-24 | Layoff |
| Visionworks (Central Region) | Syracuse | 74 | 2020-04-22 | Closure |
| Eat'n Park Hospitality Group, Inc. (Parkhurst Dining Services) (Excellus BC & BS) Central | Syracuse | 0 | 2020-04-17 | Layoff |
| Bed Bath & Beyond (Central Region) | Syracuse | 88 | 2020-04-13 | Closure |
| Abercrombie & Fitch, abercrombie kids, Hollister Co., and Gilly Hicks (2 sites) | Syracuse | 83 | 2020-04-10 | Closure |
| Crestline Hotels & Resorts dba Courtyard Syracuse Downtown at Armory Square and Residence In Syracuse Downtown | Syracuse | 36 | 2020-04-07 | Layoff |
