| Newbold Services, LLC | Breinigsville, Easton, Carlisle, York, Hazelton | 294 | 2024-01-01 | Layoff |
| Bon Appetit Management Company | Easton | 194 | 2023-05-01 | Closure |
| Morrison HealthCare | Allentown, Hazelton, Bethlehem, East Stroudsburg, Pottsville, Easton, Lehighton, Dickson City | 478 | 2023-01-01 | Layoff |
| Molded Acoustical Products (MAP) of Easton, Inc | Easton | 55 | 2021-12-01 | Closure |
| Georgia Pacific Dixie Products | Easton | 190 | 2021-01-01 | Closure |
| Steward Easton Hospital | Easton | 694 | 2020-05-01 | Closure |
| Morrison Healthcare | Easton | 38 | 2020-05-01 | Closure |
| C.F. Martin & Company, Inc - 3 locations | Nazareth, Easton | 434 | 2020-04-01 | Closure |
| Schutt Sports (Kranos Corporation) | Easton | 50 | 2018-09-01 | Closure |
| Huntsman P&A Americas LLC/ Venator Materials Corporation | Easton | 79 | 2017-09-01 | Closure |
| Lehigh Valley Media Group | Easton | 22 | 2015-03-01 | |
| Lehigh Valley Medi Group | Easton | 87 | 2014-04-01 | |
| Kindred Hospital - Easton SCCI Hospital - Easton, Inc | Easton | 105 | 2014-02-01 | |
| *UPDATE* Orograin Bakeries Manufacturing, Inc | Easton | 51 | 2014-02-01 | |
| *UPDATE* Orograin Bakeries Manufacturing, Inc | Easton | 60 | 2014-01-01 | |
| Bimbo Bakeries Orograin Bakeries Manufacturing, Inc | Easton | 151 | 2013-11-01 | |
| Sodexo, Inc. Lafayette College | Easton | 170 | 2013-05-01 | |
| BMW of North America, LLC | Easton | 95 | 2013-04-01 | |
| Hostess Brands, Inc | Easton | 29 | 2012-05-01 | |
| Cenveo Corporation | Easton | 195 | 2012-03-01 | |
