| Southwest Airlines, Co | Multiple Locations | 0 | 2020-12-03 | Layoff |
| Avis Budget Car Rental, LLC | Multiple Locations | 7 | 2020-08-28 | Layoff |
| Enterprise Holdings - IT | Multiple Locations | 23 | 2020-06-24 | Layoff |
| Cerner Corporation | Multiple Locations | 48 | 2020-06-24 | Layoff |
| LM Services Corporation d/b/a: Hilton Garden Inn-O'Fallon, Hilton Garden Inn-Chesterfield, Hilton Garden Inn-St.Louis Airport, Hilton St. Louis at the Ballpark, Holiday Inn Forest Park, Homewood Suites by Hilton-Maryland Heights, Embassy Suites by Hilton St. Louis Airport, Doubletree by Hilton, Sheraton Westport, Union Station Hotel, The Cheshire, Boundary/Basso, Doubletree Hotel & Conference Center, Hilton St. Louis Airport, Hospitality Audio Visual, Crowne Plaza St. Louis Airport, Marriott St. Louis Airport | Multiple Locations | 1,488 | 2020-06-04 | Layoff |
| Mercy Hospital - St. Louis | Multiple Locations | 663 | 2020-05-22 | Layoff |
| OS Restaurant Services LLC (Blooming Brands, d/b/a: Bonefish, Carrabba’s, Flemings, & Outback) | Multiple Locations | 935 | 2020-04-27 | Layoff |
| Enterprise Transport - Various | Multiple Locations | 447 | 2020-04-27 | Layoff |
| Great Plains Specialty Finance, Inc | Multiple Locations | 12 | 2020-04-27 | Layoff |
| Enterprise Holdings | Multiple Locations | 377 | 2020-04-27 | Layoff |
| Enterprise Holdings | Multiple Locations | 366 | 2020-04-27 | Layoff |
| EAN Services, LLC | Multiple Locations | 59 | 2020-04-27 | Layoff |
| Visionworks | Multiple Locations | 94 | 2020-04-22 | Layoff |
| Avis Budget Car Rental, LLC and its subsidiaries | Multiple Locations | 163 | 2020-04-17 | Layoff |
| Pinnacle Healthcare System, Inc | Multiple Locations | 125 | 2020-04-17 | Closure |
| Hooters of America, LLC (multiple locations) | Multiple Locations | 321 | 2020-04-07 | Layoff |
| Trans State Airlines, LLC | Multiple Locations | 718 | 2020-03-19 | Closure |
| Schmidt Restaurant Group LLC d/b/a Salt + Smoke (St. Louis - 75, University City - 84 & St. Charles - 59) | Multiple Locations | 218 | 2020-03-18 | Layoff |
| Cowley Distributing, Inc. (Cape Girardeau, Jefferson City, Maryland Heights, Springfield) | Multiple Locations | 115 | 2019-10-29 | Closure |
| Cerner | Multiple Locations | 80 | 2019-10-02 | |
